Scientists at the University of Exeter have discovered a potential breakthrough in the treatment of Alzheimer’s disease, with a drug that could halt or even reverse the disease’s progression. The drug, known as BACE1 inhibitor, has shown promise in reducing the level of amyloid beta proteins in the brain, a leading cause of Alzheimer’s.
Despite the initial optimism, trials of BACE1 inhibitors have so far yielded disappointing results, with the treatment often leading to unwanted side effects. However, the Exeter team has found a potential solution to this issue. By combining the BACE1 inhibitor with another drug, known as an NHE6 inhibitor, they were able to significantly reduce the side effects.
The combined drug treatment was tested on fruit flies, which share 70% of human genes. The results were promising, with the flies showing improved memory and lifespan. The next step is to test the combined treatment on mammalian models. If successful, it could lead to a new approach in Alzheimer’s treatment.
This breakthrough is a significant step forward in Alzheimer’s research. It offers hope for a disease that affects millions worldwide, and for which there is currently no cure. The combined drug treatment could potentially halt or even reverse the progression of Alzheimer’s, offering a new lease of life for those affected by the disease.
Go to source article: https://www.exeter.ac.uk/news/research/title_928490_en.html